NIH Invention Development Program Advances

Invention and Development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH

At the time of the invention of DT-MRI (or DTI), I was employed as a Staff Fellow (a postdoctoral fellow position) in the Mechanical Engineering Section (MES) of the Biomedical Engineering and Instrumentation Branch (BEIB) in the Intramural Research Program (IRP) of the National Center for Research Resources (NCRR) of the National Institutes of Health (NIH). (People in the federal government li...

Predicate Invention in Inductive Program Synthesis

In Inductive Logic Programming, predicate invention is the process of introducing a hitherto unknown predicate, and its description, into the description of the currently learned predicate. This is only necessary when a finite axiomatization of the current predicate is otherwise impossible, in which case the description of the invented predicate is recursive. So necessary predicate invention is...

The NIH training grant program. A program in trouble?

The NIH Anticonvulsant Drug Development (ADD) Program: preclinical anticonvulsant screening project

reports are written for those compounds that have undergone multilevel evaluations. A report analyzes and interprets the generated data, and also compares the candidate compound's pharmacodynamic and pharmacokinetic profile to that of current clinically effective drugs. Annually, approximately ten promising compounds are considered for further development by the ADD Program. If a compound appea...

Discovery, invention, and development: human creative thinking.